The Greybull Hotel, built in 1916, was the first and largest of its kind in downtown Greybull, Wyo., to be constructed with brick and concrete. Its main commercial space has served as a bank, a clothing store and a bar; during Prohibition there was a speakeasy in the basement. The hotel’s location--at the corner of Greybull Avenue and Sixth Street and at the intersection of Wyoming Highway 14 and Wyoming Highway 16/20—was of primary importance in the early days and remains so today.